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Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
《医学前沿(英文)》 2010年 第4卷 第3期 页码 264-270 doi: 10.1007/s11684-010-0094-6
关键词: cervical lesion high risk-human papilloma virus persistent infection loading dose cervical intraepithelial neoplasia cervical cancer
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 459-462 doi: 10.1007/s11684-009-0084-8
关键词: cervical cancer human papilloma virus cervical intraepithelial neoplasia
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 471-479 doi: 10.1007/s11684-017-0602-z
Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.
关键词: universal influenza virus vaccine hemagglutinin stalk H7N9
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
《医学前沿(英文)》 2020年 第14卷 第2期 页码 136-148 doi: 10.1007/s11684-020-0756-y
关键词: human immunodeficiency virus type 1 molecular cluster transmission cluster risk network targeted intervention evaluation
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 1-5 doi: 10.1007/s11684-014-0309-3
Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.
Human monoclonal antibodies as candidate therapeutics against emerging viruses
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 462-470 doi: 10.1007/s11684-017-0596-6
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.
关键词: human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus
《环境科学与工程前沿(英文)》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1475-6
• The concentrations of 13 heavy metals in Taihu Lake were analyzed.
关键词: Heavy metals Human health ambient water quality criteria Taihu Lake Health risk assessment Contribution rate
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 399-411 doi: 10.1007/s11684-010-0170-y
关键词: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional activation
《医学前沿(英文)》 2022年 第16卷 第4期 页码 584-595 doi: 10.1007/s11684-021-0844-7
关键词: hemophilia A adeno-associated virus (AAV) human/rat hybrid factor VIII gene therapy dual chain strategy
Human reliability in maintenance task
Pacaiova HANA,
《机械工程前沿(英文)》 2010年 第5卷 第2期 页码 184-188 doi: 10.1007/s11465-010-0002-4
关键词: maintenance risk assessment failure reliability prevention
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 189-195 doi: 10.1007/s11684-017-0533-8
Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.
关键词: obstructive sleep apnea Berlin Questionnaire Chinese surgical patients adverse respiratory event
Xinshu Jiang, Yingxi Qu, Liquan Liu, Yuan He, Wenchao Li, Jun Huang, Hongwei Yang, Gang Yu
《环境科学与工程前沿(英文)》 2019年 第13卷 第2期 doi: 10.1007/s11783-019-1109-4
• 39 PPCPs were investigated at a DWTP using the Yangtze River as its water source. • Grab and continuous sampling were conducted for the comparison of data consistency. • Ketoprofen & carbamazepine can be risk management indicators because of the high RQ.
王德江,孙剑平
《中国工程科学》 2010年 第12卷 第9期 页码 84-89
在对军工研究所R&D人力资本投资风险因素进行识别的基础上,建立风险评价指标体系,发现指标之间存在相互影响与反馈的关系,提出基于网络分析法并同时考虑评估意见模糊性的军工研究所R&D人力资本投资风险模糊评估模型,给出相关算法。最后,通过实例说明该方法的分析结果更合理、直观,而且还能为决策者提供更为详细的决策信息。
关键词: R&D人力资本投资风险 模糊 ANP 军工研究所
《医学前沿(英文)》 2021年 第15卷 第6期 页码 903-912 doi: 10.1007/s11684-021-0871-4
关键词: homocysteine hyperhomocysteinemia H-type hypertension Chinese
标题 作者 时间 类型 操作
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
期刊论文
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Universal influenza virus vaccines: what can we learn from the human immune response following exposure
null
期刊论文
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
期刊论文
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
null
期刊论文
Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake
期刊论文
Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
期刊论文
correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human
期刊论文
Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potentialhigh risk of adverse respiratory events in post anesthesia care unit
null
期刊论文
PPCPs in a drinking water treatment plant in the Yangtze River Delta of China: Occurrence, removal and risk
Xinshu Jiang, Yingxi Qu, Liquan Liu, Yuan He, Wenchao Li, Jun Huang, Hongwei Yang, Gang Yu
期刊论文